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| | Combinatorial Chemistry Prerequisites include Undergraduate science or science-related degree, or familiarity with the life sciences via industry participation
Duration: 1 Hour
Certificate of Completion:
Provided immediately upon successful completion. |
Ordering For Multiple Users (training 10 - 200 users, annually) see GeneEd's On Demand Training |
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 Combinatorial Chemistry
Description: The course introduces the use of combinatorial chemistry for drug discovery. It covers the requirements for performing combinatorial chemistry, the design and synthesis of combinatorial libraries, and molecular diversity analysis as applied to antibodies, peptides, nucleic acids, and small molecules.
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SUITE: Biopharmaceutical Technology: Complete Six Course Suite
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| Combinatorial Chemistry
OUTLINE
INTRODUCTION
1. Course Information
2. Interface Tour
3. Course Overview
COMBICHEM OVERVIEW
2. Objectives
3. Medicinal Chemistry
4. Combinatorial Chemistry
5. High-Throughput Screening
6. HTS Assays
7. uHTS Requirements
8. Progress Check
DIVERSITY ANALYSIS
9. Objectives
10. Selection and Diversity
11. Peptide Libraries
12. DNA Shuffling
13. Strategic Options
14. Molecular Diversity
15. Synthesis Strategies
16. Phage Display
17. Progress Check
LIBRARY DESIGN
18. Objectives
19. Drug Pharmacophores
20. Library Design
21. Lead Optimization
22. Applications
23. Progress Check
| | Combinatorial Chemistry
OBJECTIVES
Students completing this course, Combinatorial Chemistry, should be able to:
Define the two technologies that now allow the creation of large combinatorial libraries of compounds
List the three functions that combinatorial chemistry brings to synthetic medicinal chemistry
Describe the difference between the three different types of assays with which combinatorial libraries are usually tested
Specify two of the features of an assay that allow it to be amenable to high-throughput screening
Explain the advantages of HTRF-based assays
Describe the three principal requirements needed to scale an assay to the level of uHTS
Define the difference between a diverse library and a focused or biased library
Calculate the number of combinations of molecules capable of being created from an n-mer peptide library
List three classes of proteins that have been "improved" using DNA shuffling
Specify the strategic options available in the creation of a combinatorial library
Describe how molecular diversity can be obtained in protein, peptide, nucleic-acid or small-molecule libraries
Define and explain the two major strategies for synthesizing small-molecule libraries
List the nine steps involved in creating antibodies via phage display
Understand the key features of a drug pharmacophore
List some of the parameters involved in designing combinatorial drug libraries
Define the two major parameters in drug optimization that can benefit from drug design
Give two examples of drugs that can now be synthesized by solid-phase combinatorial synthesis
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BROWSE COURSES BY CATALOG:
| Best Practices in Biopharma Manufacturing | Best Practices in Clinical Research | Biotechnology & Genetics | Major Therapeutic Areas | Pharmaceutical and Healthcare Codes of Conduct |
BROWSE OTHER COURSES BY DISCIPLINE:
| Anatomy and Physiology | Bioinformatics | BioPharma | Cardiovascular System | Central Nervous System (Neurology) | Diabetes | Gastrointestinal System | Good Clinical Practice (GCP) | Good Laboratory Practice (GLP) | Good Manufacturing Practice (GMP) | Immunology | Infection | IS/IT Series | Marketing & Selling | Medical Devices | Musculoskeletal System | Oncology | Ophthalmology | Pain | Psychiatric Disorders | Quality Control (QC) | Respiratory System | Urology | Validation |
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